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Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 155-169 doi: 10.1007/s11684-021-0848-3

Abstract: Hepatic resection represents the first-line treatment for patients with resectable hepatocellular carcinomaavailable evidence for the efficiency of adjuvant treatments to prevent HCC recurrence after curative liver resectionAdjuvant hepatic artery infusion chemotherapy might be beneficial in patients with vascular invasion.

Keywords： hepatocellular carcinoma     adjuvant treatment     hepatic resection     recurrence    

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Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status

Li Jiang, Deng Ning, Xiaoping Chen

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 251-261 doi: 10.1007/s11684-019-0727-3

Abstract: pancreatic fistula (POPF) is the most common and critical complication after pancreatic body and tail resection

Keywords： pancreatic fistula     pancreatic body and tail resection     distal pancreatectomy    

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loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor resection

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4,   Pages 536-545 doi: 10.1007/s11705-021-2067-5

Abstract: More attention should be given to local inhibition of recurrence after glioblastoma resection to meetsustained release and prolonged therapeutic effect of drugs for inhibiting tumor recurrence after tumor resectionThe hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removalin a fully characterized resection rat model.implantation and delivery may provide a reliable method to inhibit the recurrence of glioblastoma after tumor resection

Keywords： BCNU     glioblastoma recurrence     tumor resection     nanoparticles     hydrogel    

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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract: As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), servingAs supported by the results from both human and animal studies, metformin improves hepatic steatosisMechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine

Keywords： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

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Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 191-202 doi: 10.1007/s11684-017-0512-0

Abstract:

Primary hepatic carcinoma (PHC) is a common malignant tumor in China.review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic

Keywords： traditional Chinese medicine     primary hepatic carcinoma     meta-analysis    

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Urotensin II receptor antagonist reduces hepatic resistance and portal pressure through enhanced eNOS-dependent

Ruoxi Zhang, Jing Chen, Diangang Liu, Yu Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 398-408 doi: 10.1007/s11684-019-0689-5

Abstract: receptor (UT) antagonist palosuran on rats with carbon tetrachloride (CCl )-induced cirrhosis, the hepaticfibrosis, the metalloproteinase-13 (MMP-13)/ tissue inhibitor of metalloproteinase-1 (TIMP-1) ratio, hepaticPrimary hepatic stellate cells (HSCs) are used to investigate the changes in UII/UT expression and thethat long-term administration of palosuran can decrease PP in cirrhosis, which results from decreased hepatic

Keywords： portal hypertension     cirrhosis     urotensin II     palosuran     hepatic stellate cell    

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Beneficial effects of preventive cholecystectomy in patients with hepatic cancer

LIU Anzhong, LI Jun, HUA Huwei

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 139-142 doi: 10.1007/s11684-008-0026-x

Abstract: is no conclusive answer to the question whether excising gall bladder is helpful to the patient with hepaticThe survival rate of patients with hepatic cancer for more than two years has been increased, and thestone are relatively higher among these patients, which may seriously complicate treatment of advanced hepaticfrom 2002 to 2006 to assess the clinical significance of preventive cholecystectomy in patients with hepaticOne hundred and eighteen cases of postoperative patients with hepatic cancer, who survived for more than
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Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 317-321 doi: 10.1007/s11684-012-0203-9

Abstract: indicators predicting prognosis of malignant gastrointestinal stromal tumors (GISTs) after surgical resectionand necrosis also influence on the long-term survival of patient with malignant GISTs after surgical resection

Keywords： gastrointestinal stromal tumors     surgery     survival    

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Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 154-165 doi: 10.1007/s11684-008-0029-7

Abstract: In order to investigate the effect of paeoniflorin (PAE) on hepatic fibrosis of mice with and , a modelof hepatic fibrosis caused by schistosomiasis was established in mice infected with cercariae of .Hepatic granuloma and fibrosis were evaluated via HE and Masson staining. The expression of ?1 in optimum macrophage-conditioned medium (OPMCM) on the proliferation of hepatic stellate cells (HSCsIn a word, PAE can prevent hepatic granuloma and fibrosis caused by schistosomiasis japonica through

Keywords： cercariae     collagen     hyaluronic     OPMCM     soluble    

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Endoscopic resection of a huge Brunner's gland adenoma

ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 414-418 doi: 10.1007/s11684-008-0080-4

Abstract: Brunner’s gland adenoma is a rare tumour of the duodenum, which is usually benign. A 71-year-old woman presenting with epigastric pain, upper gastrointestinal haemorrhage and melaena was reported in this paper. Upper gastro-intestinal (GI) endoscopy revealed a large pedunculated tumour on the superior part of the duodenal bulb. Endoscopic polypectomy was successfully performed by clipping and nylon thread without any complications. Histological examination revealed a Brunner’s gland adenoma.

Keywords： superior     Histological examination     endoscopy     gastro-intestinal     gastrointestinal haemorrhage    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: the secretion of angiotensin II (ANG II) and the expression of angiotensin receptor type 1 (AT1R) in hepaticprotein expression of AT1R, which may be the mechanism by which β-elemene prevents the progress of hepatic

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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Immunohistochemical characterization of hepatic stem cell-related cells in developing human liver

XU Jun, HU Yong, WANG Jian, ZHANG Taiping, ZHOU Ji, YU Hongyu

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 264-268 doi: 10.1007/s11684-007-0050-2

Abstract: Little is known about the expression characteristics of the various kinds of possible markers in hepaticH-E staining and immunohistochemical methods were used to observe the expression of hepatic/cholangiocellularGST- was detected in hepatic cord cells from the sixth week and in the ductal plate cells from the eighthCK19 expression peaks during the 6th–11th weeks in hepatic cord cells and decreases gradually afterwardsAt 16 weeks’ gestation, most hepatic cord cells begin to differentiate into hepatocytes and abundant

Keywords： origin     Little     mesenchymal tissue     cords/mesenchymal tissue     CD34    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract:

Gene therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directed gene transfer mediated by adeno-associated viral vectors. Recent clinical trials involving the use of a self-complementary adeno-associated virus serotype 8-human codon-optimized factor IX (AAV8-hFIXco) vector demonstrated encouraging efficacy with hFIX expression stabilized at 1% to 6% of normal level in patients, but safety concerns related to high vector doses are still present. Thus, further improvement of AAV vectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B gene therapy. In this study, to obtain a higher expression level of hFIX that potentiates the coagulant capacity of recipients, human FIX expression vector was optimized by upgrading the codon adaption index and adjusting the GC content, inserting a Kozak sequence (GCCACC), and introducing a gain-of-function mutation, R338L (FIX Padua). The efficiency of the published and the presently constructed cassettes was compared through in vivo screening. In addition, the regulatory elements that control the FIX gene expression in these cassettes were screened for liver-specific effectiveness. Among all the constructed cassettes, scAAV-Pre-hFIXco-SIH-R338L, which was the construct under the control of the prothrombin enhancer and prealbumin promoter, resulted in the highest level of coagulant activity, and the expression levels of two constructed cassettes (scAAV-Chi-hFIXco-SIH-R338L and scAAV-Pre-hFIXco-SIH-R338L) were also higher than that of the published cassette (scAAV-LP1-hFIXco-SJ). In summary, our strategies led to a substantial increase in hFIX expression at the protein level or a remarkably elevated coagulant activity. Thus, these reconstructs of hFIX with AAV vector may potentially contribute to the creation of an efficacious gene therapy of hemophilia B.

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosisand intervention of resveratrol as well as the way by which integrin-β1 promoted hepatic fibrosis.Hepatic fibrosis models of male Sprague Dawley (SD) rats were created and intragastric administrationgrowth factor-β (TGF-β) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in different stages of hepaticas the development of hepatic fibrosis.

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 317-322 doi: 10.1007/s11684-010-0035-4

Abstract: The inhibitory effect of different reperfusion periods 45 min following hepatic ischemia on the expressionrat model of I/R was established by using a non-invasive artery clamp to clip (45 min) or relax the hepaticand salvia miltiorrhiza injection (6 g/kg) were injected via the tail vein 30 min before clipping the hepaticIn the SO group only the porta hepatis was dissected after laparotomy without clamping the hepatic pedicle

Keywords： hepatic ischemia-reperfusion     digestive tract congestion     cholecystokinin     vasoactive intestinal peptide    

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Title Author Date Type Operation

Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Journal Article

Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status

Li Jiang, Deng Ning, Xiaoping Chen

Journal Article

loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor resection

Journal Article

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Journal Article

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Journal Article

Urotensin II receptor antagonist reduces hepatic resistance and portal pressure through enhanced eNOS-dependent

Ruoxi Zhang, Jing Chen, Diangang Liu, Yu Wang

Journal Article

Beneficial effects of preventive cholecystectomy in patients with hepatic cancer

LIU Anzhong, LI Jun, HUA Huwei

Journal Article

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Journal Article

Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Journal Article

Endoscopic resection of a huge Brunner's gland adenoma

ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

Immunohistochemical characterization of hepatic stem cell-related cells in developing human liver

XU Jun, HU Yong, WANG Jian, ZHANG Taiping, ZHOU Ji, YU Hongyu

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Journal Article